DmelPPI Project: Comprehensive understanding interaction details of protein-protein interactions in Drosophila melanogaster

Welcome to the DmelPPI project! In this project, we studied the physical interactions between proteins at the genomic scale. We aim to obtain a comprehensive physical interaction network by combining AlphaFold2 multimer predictions and the STRING PPI database. The reason we chose STRING database is that it not only contains physical PPIs curated or inferred from other databases, but also contains functional PPIs including co-expression. It was reported by several studies (Grigoriev 2001, Jansen et al 2003, Ramani et al 2008) that co-expressed proteins have higher chances to physically interact with each other than random expectations. The DmelPPI database currently contains more than 3,600 high confident structure models and additional 7,000 plausible interactions out from 27,711 non-redundant high-quality physical and functional PPIs inferred from STRING database, with more to come in the future. These structure models provide a comprehensive landscape to understand the interaction details within the Drosophila genome.

If you have any suggestions or feedback, we would be grateful if you could share them with us. Kindly direct your thoughts to: Junhui Peng and Li Zhao. If you are interested in our research, check Zhao Lab Homepage at Rockefeller University for detail.

Main Table. AlphaFold2 multimer predictions of 27,711 PPIs inferred from STRING database.
Please click "View Details" for detailed information about the predicted AF2 model. There is also a search box where you can search your favorite genes or proteins.
search examples: "Ku80", "Ku80 Irbp".